Natural and Synthetic Furanones with Anticancer Activity

Synthetic advances in macrosphelides: natural anticancer agents.

Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.

Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity.

Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and f...

Natural Based Anticancer Drugs and Their Worthiness

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation. In the nucleus, Nrf2 increases antioxidant gene expression and reduces pro-inflammatory gene expression. By increasing Nrf2 activity, AIMs reduce reactive oxygen species and inflammation in the...

Natural and synthetic materials with insect hormone activity. 9. Structure- juvenile activity relationships in simple peptides.

Tritium-Aktivität in den extrahierten Metaboliten zwischen 90 — 95% liegt, beweist, das Hydroxylierungen, Bindung an Protein oder Abbau des Steroidgerüstes zu nichtSteroiden Verbindungen in der Mikrosomenfraktion der Rattenplacenta ohne praktische Bedeutung sind [s. auch Diskussionsbemerkung bei B R E U E R et al .9 ] . Über die Bedeutung der bisher nicht bekannten Zellfunktion des NAD®-abhängi...